Prediction: San Diego Padres VS San Francisco Giants 2025-06-04

The San Diego Padres are set to face off against their NL West rivals, the San Francisco Giants, in what promises to be a thrilling matchup. The Giants are currently favored to win, with odds of -148, and for good reason - they've got a strong record as moneyline favorites, winning 61.1% of their games. Meanwhile, the Padres have struggled as underdogs, winning only 36.4% of their games when favored by +125 or more.

But don't count out the Padres just yet. They've got a strong pitching staff, with a 3.63 ERA that's ninth-best in baseball. And with players like Fernando Tatis Jr. and Manny Machado on their roster, they've got the potential to put up some big numbers.

That being said, the Giants have a strong offense, ranking 16th in MLB with 4.2 runs per game. And with players like Jung Hoo Lee, Heliot Ramos, and Wilmer Flores leading the charge, they're likely to give the Padres' pitching staff a run for their money.

So, what's my prediction for this matchup? I've got to go with the under on the total runs scored. With two strong pitching staffs facing off against each other, I think we're looking at a low-scoring game. The odds for the under are currently sitting at around 1.81, which I think is a steal. The Padres and Giants have already shown us that they can play a tight, low-scoring game, with their previous matchup ending in a 1-0 Padres win in the 10th inning.

My best bet for this game is: Under 7.5 runs (-105 on FanDuel). I think this is a solid bet, given the strength of both teams' pitching staffs and the fact that they've already shown us that they can play a low-scoring game. So, if you're looking to make some money on this matchup, I'd recommend taking the under.

Created: June 4, 2025, 1:50 a.m. GMT