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Prediction: St. Louis Cardinals VS Chicago Cubs 2025-09-26

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Cardinals vs. Cubs: A Tale of Two Motivations (and One Team That’s Already Checked Out)

The St. Louis Cardinals and Chicago Cubs meet on September 26 in a game that’s less about playoff destiny and more about the Cardinals’ quest to lose with style. Let’s break down why the Cubs are the clear favorites here—statistically, emotionally, and literally in the standings.


Parsing the Odds: Why the Cubs Are the Smart Bet
The betting lines tell a story of a team (Cubs) with everything to play for and another (Cardinals) that’s already checked out. Chicago is listed at -150 (decimal: 1.57), implying a 61% implied probability of victory. St. Louis, meanwhile, sits at +246 (decimal: 2.46), or 29% implied odds. That’s a 32% gap in perceived chances—a chasm in baseball terms.

The total runs line is set at 9 runs, with even money on Over/Under. Given that the Cardinals’ starter, Miles Mikolas, has a career ERA of 3.82 and the Cubs’ offense is hitting .245 this season, this feels like a “low-scoring thriller” waiting to happen—or a “let’s just go home early” snoozer.


Recent News: The Cardinals Are Emotionally Bankrupt
The Cardinals were mathematically eliminated from playoff contention last night after a 4-3 loss to the Giants. Their starter, Sonny Gray, pitched six solid innings but couldn’t outduel the Giants’ bullpen. The Cardinals’ relievers? A collective yawn. Kyle Leahy (who failed to retire runners in the 7th inning) is likely to start again, and his 2025 ERA of 5.12 suggests he’s more “fireworks” than “firewall.”

Meanwhile, the Cubs are still alive in the NL Wild Card race. They’ll send Miles Mikolas to the mound—a pitcher who’s somehow managed to strike out 200+ batters in back-to-back seasons while making fans question their life choices. Mikolas is a 34-year-old enigma, but at least he’s better than the Cardinals’ current rotation, which looks like it was assembled by rolling a dice.


The Humor: Why This Game Is a Foregone Conclusion
The Cardinals are playing like they’ve already accepted their post-season job applications at the Hall of Fame gift shop. Their offense? A group of guys who think “small ball” means ordering takeout. Their defense? A relay race where the ball always drops at the final base.

The Cubs, meanwhile, are fighting like a swarm of angry bees. They need this win to keep their playoff hopes alive, and Mikolas is out to prove he’s not just a “has-been” (a label he’s been wearing since 2018). Imagine the Cardinals’ dugout: “Relax, fellas, we’re just here to make the Cubs sweat. No pressure!”

And let’s not forget the Wrigley Field factor. The Cubs’ home park is a pitcher’s paradise, but the Cardinals’ offense is so anemic, they’d struggle to score in a nuclear winter.


Prediction: Cubs Win, Cardinals Check Out
The Cubs win 4-2 behind Mikolas’ seven innings of two-run ball and a late-inning RBI double from Ian Happ (who’s been hitting for the cycle every other game since 2019). The Cardinals’ offense will manage three hits, two of which are ground-rule doubles that rolled into the parking lot.

Why?
1. Motivation: The Cubs have playoff pressure; the Cardinals have none.
2. Starting Pitching: Mikolas > Cardinals’ rotation (which is like a “mystery meat” combo of journeymen).
3. Run Line: The Cubs’ -1.5 spread is achievable if Mikolas limits damage and the offense scrapes together a few runs.

Final Score Prediction: Cubs 4, Cardinals 2. The Cardinals will tip their caps, grab their Gatorade, and head to the airport—literally flying south for the winter.

Bet the Cubs unless you enjoy watching teams perform like they’re in a “how to lose” seminar. The Cardinals? They’re here to teach the final lesson: “How to quit.” 🐾⚾

Created: Sept. 26, 2025, 6:20 a.m. GMT

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